[Effect of exercise on leptin in streptozotocin-induced diabetic rats]

The effect of exercise on leptin in streptozotocin(STZ)-induced diabetic rats was investigated. Four group of SD rats (10 in each group) including exercise STZ diabetic group, non-exercise STZ diabetic group, exercise normal group and non-exercise normal group were used in the study. Exercise groups were treated with treadmill. The results showed that: (1) blood glucose of STZ diabetic rats was higher, serum insulin, C-peptide and leptin level were lower than that of normal rats; (2) blood glucose was decreased, and blood insulin and C-peptide were increased in exercised STZ diabetic group. The levels of leptin in plasma, brain and adipose tissue were increased in exercise groups. It is concluded that appropriate exercise training may have impacts on insulin and leptin production to correct the abnormal glucose metabolism and energy metabolism in diabetic rats.