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TSH stimulates leptin secretion by a direct effect on adipocytes
C Menendez1, R Baldelli, J P Camiña
1Department of Medicine, Research Area, Molecular Endocrinology Laboratory, Complejo Hospitalario Universitario de Santiago (CHUS), University of Santiago de Compostela, Santiago de Compostela E-15782, Spain.
The Journal of Endocrinology
|January 15, 2003
Summary
Thyroid-stimulating hormone (TSH) powerfully stimulates leptin secretion from human adipose tissue in vitro. This suggests a dual relationship between leptin and the thyroid axis, potentially influencing leptin pulses.
Area of Science:
- Endocrinology
- Metabolism
- Adipose Tissue Biology
Background:
- Leptin, a hormone from adipose tissue, regulates energy homeostasis and neuroendocrine functions.
- While leptin influences pituitary hormones, the effect of pituitary products on leptin release is largely unknown.
- Coordinated pulsatility observed between leptin and TSH suggests a potential interaction.
Purpose of the Study:
- To investigate the direct effect of TSH on in vitro leptin secretion from human adipose tissue.
- To determine if other pituitary hormones (prolactin, ACTH, FSH, LH) influence leptin release.
Main Methods:
- Organ cultures of human omental adipose tissue from 34 surgical patients.
- Incubation of adipose tissue with TSH and other pituitary hormones.
- Measurement of leptin secretion in vitro.
Main Results:
- TSH significantly stimulated leptin secretion from human adipose tissue.
- Prolactin, ACTH, FSH, and LH did not affect leptin secretion.
- Demonstrated a direct stimulatory effect of TSH on adipose tissue leptin release.
Conclusions:
- Leptin and the thyroid axis share a complex, dual regulatory relationship.
- TSH is a potent stimulator of leptin secretion.
- Changes in plasma TSH may contribute to the regulation of leptin pulses.