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Frequency and phenotype of circulating Valpha24/Vbeta11 double-positive natural killer T cells during hepatitis C
Michaela Lucas1, Stephan Gadola, Ute Meier
1Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, United Kingdom.
Abstract:
Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Valpha24/Vbeta11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Valpha24/Vbeta11 NKT cells found in blood, those in the liver appeared to be recently activated.
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