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Longstanding ataxic demyelinating polyneuronopathy with a novel autoantibody
Douglas W Zochodne1, Roland Auer, Marvin J Fritzler
1Department of Clinical Neurosciences, Faculty of Medicine, University of Calgary, Alberta, Canada. dzochodn@ucalgary.ca
Neurology
|January 15, 2003
Abstract:
The authors describe the clinical course, postmortem findings, and characterization of a novel autoantibody (anti-M-phase phosphoprotein-1 [anti-MPP-1]) in a patient with a longstanding acquired demyelinating polyneuropathy and neuronopathy. Postmortem examination identified active sensory neuron degeneration, sensory axon loss, and widespread peripheral nerve demyelination. A possible pathophysiologic role of anti-MPP-1 is not yet identified.