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Related Experiment Videos

Autonomous activity in the isolated guinea pig bladder.

M J Drake1, I J Harvey, J I Gillespie

  • 1School of Surgical and Reproductive Sciences, 3rd floor Leech building, The Medical School, University of Newcastle, NE2 4HH, UK.

Experimental Physiology
|January 15, 2003
PubMed
Summary

The bladder exhibits complex autonomous activity, generating spontaneous micro-contractions and waves independent of neural control. This intrinsic bladder activity contributes to phasic pressure changes, revealing its capacity for self-regulation.

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Area of Science:

  • Urology
  • Physiology
  • Smooth Muscle Biology

Background:

  • Phasic pressure changes in the bladder can occur independently of micturition.
  • In vitro and ex vivo studies suggest the bladder possesses autonomous activity.
  • The origin of spontaneous bladder activity in the intact organ remains unclear.

Purpose of the Study:

  • To investigate the presence and characteristics of autonomous activity in the isolated guinea pig bladder.
  • To determine if the bladder wall can generate spontaneous contractions.
  • To understand the coordination of autonomous activity within the intact bladder.

Main Methods:

  • Utilized multiple-point motion analysis and concurrent intravesical pressure recording in isolated guinea pig bladders.
  • Quantified spontaneous and evoked muscle activity.

Related Experiment Videos

  • Assessed the effects of autonomic agents (atropine, tetrodotoxin, arecaidine) on bladder activity.

    • Main Results:

    • Observed complex autonomous activity in unstimulated bladders, including localized micro-contractions, activity waves, and micro-stretches.
    • Recorded low-amplitude phasic 'micro-transients' in intravesical pressure correlated with micro-contractions.
    • Found that atropine and tetrodotoxin did not affect micro-transients or micro-contractions, while arecaidine coordinated activity into pressure rises and contraction waves.

    Conclusions:

    • The bladder wall generates and coordinates complex autonomous activity, independent of neural input.
    • Intrinsic bladder activity contributes to phasic pressure changes.
    • Assessing the integrative properties of the entire bladder organ is crucial for understanding bladder physiology and pathophysiology.