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Fluoride controlled release tablets for intrabuccal use.

M Diarra1, G Pourroy, C Boymond

  • 1Laboratoire de Physique, Faculté de Médecine et de Pharmacie, Université Cheikh Anta Diop, DAKAR, Senegal.

Biomaterials
|January 16, 2003
PubMed
Summary
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This study presents a novel fluoride delivery system for teeth, using hydroxyapatite tablets for effective, localized fluoride release with fewer side effects. The impregnation method offers the most reproducible results for this dental therapeutic.

Area of Science:

  • Dental Materials Science
  • Drug Delivery Systems
  • Biomaterials

Background:

  • High local fluoride concentrations are therapeutically desirable for dental applications.
  • Existing delivery systems may have limitations in achieving sustained release or minimizing side effects.

Purpose of the Study:

  • To develop and characterize a novel controlled fluoride release system for intra-buccal use.
  • To evaluate the impact of matrix composition and sodium fluoride (NaF) incorporation methods on drug release profiles.

Main Methods:

  • Formulation of 160-200mg tablets with a hydroxyapatite matrix, incorporating Eudragit® and/or ethylcellulose.
  • Sodium fluoride (NaF) was incorporated via mechanical mixing or impregnation.
  • In vitro drug release studies were conducted in saline phosphate buffered solution using a fluoride-selective electrode.

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Main Results:

  • Linear fluoride release profiles were observed when ethylcellulose was used in the matrix.
  • The impregnation method yielded the most reproducible drug release results.
  • Eudragit® incorporation enhanced dissolution efficiency, while ethylcellulose decreased it.

Conclusions:

  • A promising controlled fluoride delivery system for intra-buccal application has been developed.
  • The choice of matrix components (Eudragit®, ethylcellulose) and NaF incorporation method significantly influences fluoride release kinetics and reproducibility.
  • This system has the potential for effective localized fluoride therapy with minimized side effects.