Related Experiment Video
Updated: Sep 27, 2026

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
Published on: August 26, 2025
Intrastent sonotherapy in pulmonary vein restenosis: a new treatment for a recalcitrant problem
C J McMahon1, C E Mullins, H G El Said
1Lillie Frank Abercrombie Division of Pediatric Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston 77030, USA. cmcmahon@bcm.tmc.edu
Insights
Recurrent pulmonary vein stenosis in a child was treated with balloon dilation and intrastent sonotherapy. This novel approach significantly improved the patient's condition and reduced pulmonary hypertension.
Area of Science:
- Cardiovascular Surgery
- Pediatric Cardiology
- Interventional Cardiology
Background:
- Pulmonary vein stenosis (PVS) is a serious complication after surgical repair of infradiaphragmatic pulmonary venous connection.
- Recurrent PVS necessitates multiple interventions, posing significant challenges in pediatric patients.
Observation:
- A 2-year-old boy with recurrent PVS experienced severe neointimal proliferation in previously implanted pulmonary vein stents.
- The patient presented with suprasystemic right ventricular pressure, indicating significant pulmonary hypertension.
Findings:
- Simultaneous balloon dilation and intrastent sonotherapy were performed to address the severe neointimal proliferation.
- Three months post-intervention, the patient showed significant clinical improvement, with decreased right ventricular pressure and Doppler velocity across the stents.
Implications:
- Intrastent sonotherapy combined with balloon angioplasty presents a promising therapeutic option for managing recurrent pulmonary vein stenosis.
- This approach may offer a less invasive alternative to repeat surgeries, improving outcomes for pediatric patients with complex congenital heart disease.
Abstract:
A 2 year old boy developed recurrent pulmonary vein stenosis after surgical repair of infradiaphragmatic pulmonary venous connection. He had required implantation of stents in the left and right sided pulmonary veins at 7 and 13 months of age, respectively. By 2 years of age he had undergone three catheterisation procedures and two surgical procedures to treat recurrent pulmonary vein stenosis. His right ventricular pressure was suprasystemic and catheterisation showed severe neointimal proliferation of both left and right sided stents. At this time the stents were dilated by balloon with simultaneous intrastent sonotherapy. Three months later the patient's clinical improvement was significant, his right ventricular pressure had decreased, and Doppler velocity had decreased across both left and right sided stents.
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