Related Experiment Videos
[Bilateral diffuse uveal melanocytic proliferation associated with systemic carcinoma: two case reports]
E Frau1, M Lautier-Frau, M Labetoulle
1Consultation d'Ophtalmologie, Institut Gustave Roussy, Villejuif, France.
Journal Francais D'Ophtalmologie
|January 16, 2003
Summary
Diffuse uveal melanocytic proliferation, a rare paraneoplastic syndrome, typically causes rapid vision loss. However, this study presents two cases with slow progression and no visual impairment, suggesting a more favorable prognosis in some instances.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Diffuse uveal melanocytic proliferation (DUMP) is a rare paraneoplastic syndrome associated with systemic carcinoma.
- It typically leads to rapid, bilateral visual loss due to choroidal and ciliary body melanocyte proliferation.
- Visual impairment is often exacerbated by secondary retinal detachment and cataract.
Observation:
- Two cases of presumed DUMP are presented.
- Case 1: A 74-year-old man with a history of colic carcinoma and liver hemangioendothelioma presented with bilateral choroidal nevi and an extrascleral melanic nodule.
- Case 2: A 59-year-old woman with a history of treated thyroid carcinoma presented with bilateral choroidal nevi.
Findings:
- Neither patient showed evidence of systemic melanoma.
- Both patients exhibited slow disease progression.
- Crucially, neither patient experienced visual impairment, contrasting with typical DUMP presentations.
Implications:
- These cases suggest that DUMP may have a variable clinical course.
- The findings indicate a potentially slower progression and better visual outcomes in select patients.
- This challenges the established understanding of DUMP as uniformly leading to rapid visual deterioration.