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[A study on lyophilization injection of cucurbitacin polylactic acid nanoparticles]
1School of Pharmacy, West China University of Medical Sciences, Chengdu 610041, Sichuan, China.
Objective:
To prepare stable and redispersable Lyophilization injection of cucurbitacin polylactic acid nanoparticles(Cu-PLA-NP).
Method:
An optimal supporting agent was chosen to prepare the Cu-PLA-NP lyophilization injection. The physical and chemical properties of the injection were evaluated.
Results:
The shape, diameters, association ratio, drug loading and pH of Cu-PLA-NP colloidal solution and lyophilization injection were not changed. The content of water consisted with the requirement of lyophilization injection. The critical relative humidity was 69.52%. The stability was good.
Conclusion:
It is practicable to prepare Cu-PLA-NP lyophilization injection with proper formulas and preparation processes.