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[A study on lyophilization injection of cucurbitacin polylactic acid nanoparticles]
1School of Pharmacy, West China University of Medical Sciences, Chengdu 610041, Sichuan, China.
Summary
Stable cucurbitacin polylactic acid nanoparticles (Cu-PLA-NP) lyophilization injections were successfully prepared. The resulting injections maintained critical physical and chemical properties, demonstrating good stability for pharmaceutical applications.
Area of Science:
- Nanotechnology
- Pharmaceutical Sciences
- Materials Science
Background:
- Cucurbitacin polylactic acid nanoparticles (Cu-PLA-NP) offer therapeutic potential.
- Developing stable lyophilized formulations is crucial for drug delivery.
- Lyophilization enhances the stability and shelf-life of nanoparticles.
Purpose of the Study:
- To develop a stable and redispersable lyophilization injection of cucurbitacin polylactic acid nanoparticles (Cu-PLA-NP).
Main Methods:
- Selection of an optimal supporting agent for Cu-PLA-NP lyophilization injection preparation.
- Evaluation of the physical and chemical properties of the prepared injection.
- Assessment of critical parameters including shape, diameter, association ratio, drug loading, pH, water content, and critical relative humidity.
Main Results:
- The lyophilization process did not alter the shape, diameters, association ratio, drug loading, or pH of Cu-PLA-NP.
- The water content met the requirements for lyophilization injections.
- The critical relative humidity was determined to be 69.52%, indicating good stability.
Conclusions:
- The preparation of stable and redispersable Cu-PLA-NP lyophilization injection is feasible.
- Optimized formulas and preparation processes are key to successful lyophilized nanoparticle formulations.
- This study provides a viable method for producing stable Cu-PLA-NP lyophilization injections.