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[Application of Ca(2+)-ISME in the studies on pharmacokinetics of calcium supplements]
Hua Xi Yi Ke Da Xue Xue Bao = Journal of West China University of Medical Sciences = Huaxi Yike Daxue Xuebao
|January 17, 2003
Abstract
Objective:
To determined the concentration of Ca2+ in serum by a self-made Ca(2+)-ISME in order to indicate the absorption of calcium supplement.
Methods:
We have developed a calibration curve method to measure Ca2+ activities in serum sample. The pharmacokinetics of three kinds of calcium supplements were investigated by the Ca(2+)-ISME after P.O. administration in 5 healthy rats.
Results:
Though the Tmax (hours) of the three kinds of preparations were different, there were no significant differences among their AUC by paired t-text.
Conclusion:
The above results demonstrate that our self-made Ca(2+)-ISME is applicable to the researches on pharmacokinetics of calcium supplements.