Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chemosensitivity testing--present and future in Japan.

Tetsuro Kubota1, Yoshihide Otani, Toshiharu Furukawa

  • 1Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. tkubota@sc.itc.keio.ac.jp

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
|January 17, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A case of gastric granular cell tumor successfully treated by laparoscopic and endoscopic cooperative surgery.

Clinical journal of gastroenterology·2024
Same author

Profilin 2 isoform expression is associated with lung metastasis of colorectal cancer according to a comprehensive gene expression study using a mouse model.

Oncology letters·2024
Same author

Efficacy and safety of transcatheter arterial embolization of omental artery aneurysm: A single-center experience.

Asian cardiovascular & thoracic annals·2024
Same author

Standardization of the Definition and Surgical Management of Splenic Flexure Carcinoma by an International Expert Consensus Using the Delphi Technique: Room for Improvement?

Diseases of the colon and rectum·2023
Same author

A case of early gastric cancer resembling a subepithelial lesion diagnosed by endoscopic ultrasound-guided fine needle aspiration.

Clinical journal of gastroenterology·2022
Same author

Role of EphB2/ephrin-B1 signalling in the development and progression of obesity-associated colorectal cancer.

Oncology letters·2022

Chemosensitivity testing aids in selecting adjuvant chemotherapy for gastrointestinal cancer patients post-surgery. This approach improves survival rates for sensitive individuals, offering a personalized treatment strategy.

Area of Science:

  • Oncology
  • Gastroenterology
  • Pharmacogenomics

Background:

  • Radical surgery with lymph node dissection is the primary curative treatment for gastrointestinal cancer.
  • Adjuvant chemotherapy's role after surgery remains debated despite 30%-50% response rates.
  • Limitations in current adjuvant chemotherapy necessitate novel approaches for advanced gastrointestinal cancer.

Purpose of the Study:

  • To introduce and evaluate the efficacy of chemosensitivity testing for guiding adjuvant chemotherapy in advanced gastrointestinal cancer.
  • To determine if chemosensitivity testing can improve patient survival outcomes.
  • To explore the application of molecular targets in personalized cancer chemotherapy.

Main Methods:

  • Utilized chemosensitivity testing to assess patient response to various chemotherapeutic agents.

Related Experiment Videos

  • Correlated test results with patient survival data.
  • Investigated molecular targets of common antitumor agents (e.g., 5-FU, anthracyclines, platin, CPT-11).

    • Main Results:

    • Chemosensitivity testing demonstrated utility in selecting appropriate adjuvant chemotherapy.
    • Patients identified as sensitive to chemotherapy through testing showed increased survival rates.
    • Clarification of molecular targets for conventional agents facilitates clinical application.

    Conclusions:

    • Chemosensitivity testing is a valuable tool for optimizing adjuvant chemotherapy in advanced gastrointestinal cancer.
    • Combining radical surgery with chemosensitivity-guided adjuvant chemotherapy offers survival benefits.
    • The test's approval as "advanced clinical medicine" in Japan supports its clinical utility and advocates for broader insurance coverage.