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Zinc and copper complexes of prodigiosin: implications for copper-mediated double-strand DNA cleavage
Gyungse Park1, John T Tomlinson, Matt S Melvin
1Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109-7486, USA.
Organic Letters
|January 17, 2003
Abstract:
[reaction: see text] Zinc(II) and copper(II) complexes of prodigiosin (1) have been characterized. All N-atoms of 1 bind Cu(II) to generate 5: the complex exhibits regiospecific oxidation of the C-pyrrole. In contrast, coordination by Zn(II) to 1 produces Zn(1)(2) (8), a 4-coordinate tetrahedral complex. The influence of these binding geometries on Cu-mediated double-strand (ds) DNA cleavage by 1 is discussed.