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An efficient and practical N-methylation of amino acid derivatives
Mahavir Prashad1, Denis Har, Bin Hu
1Process Research and Development, Chemical and Analytical Development, Novartis Institute for Biomedical Research, One Health Plaza, East Hanover, New Jersey 07936, USA. mahavir.prashad@pharma.novartis.com
Organic Letters
|January 17, 2003
Abstract:
[reaction: see text] An efficient and practical N-methylation of amino acid derivatives with dimethyl sulfate in the presence of sodium hydride and a catalytic amount of water is described. Reaction of water with sodium hydride generated highly reactive dry sodium hydroxide, which led to much faster reaction rates than powdered sodium hydroxide itself.