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A concise formal total synthesis of TMC-95A/B proteasome inhibitors
Brian K Albrecht1, Robert M Williams
1Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
Organic Letters
|January 17, 2003
Abstract:
[reaction: see text] A formal total synthesis of proteasome inhibitors TMC-95A/B is described. The synthesis features a stereoselective modified Julia olefination and a diastereoselective dihydroxylation to construct the highly oxidized tryptophan residue.