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Intermediate dose pre-operative irradiation for carcinoma of the rectum
Takashi Uno1, Shigeo Yasuda, Takashi Aruga
1Department of Radiation Oncology, Chiba University, Graduate School of Medicine, Inohana 1-8-1, Chuou-ku, Chiba City, Chiba 260-8670, Japan. unotakas@ho.chiba-u.ac.jp
Background:
To assess the locoregional control, survival and toxicities of combined intermediate-dose pre-operative irradiation and surgery for rectal cancer patients.
Materials And Methods:
Forty-two patients with adenocarcinoma of the rectum underwent intermediate-dose pre-operative radiotherapy. The median age was 58 years. the prescribed dose was 30.6 Gy to the whole pelvis, while a boost of 4 x 3 Gy to the primary tumor was added. The calculated linear-quadratic dose was 52 Gy.
Results:
Failure as a first site was pelvic in 2 and distant in 11. The crude pelvic failure rate was 9.5%. The 3- and 5-year overall survival was 75% and 63%, respectively. Pre-operative radiotherapy was well-tolerated by all. No anastomotic breakdown was seen. Nor was any death attributable to any adverse effects of the treatment.
Conclusion:
The present results suggested that pre-operative intermediate-dose radiotherapy is effective in preventing pelvic recurrence in rectal cancer patients with acceptable toxicities.