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Rhabdomyolysis during prolonged intravenous tocolytic therapy
Yoshio Matsuda1, Yumiko Nagayoshi, Nami Kirihara
1Department of Obstetrics and Gynecology, Kagoshima City Hospital, Kagoshima. ymatsuda@obgy.twmu.ac.jp
Journal of Perinatal Medicine
|January 18, 2003
Summary
A patient on ritodrine hydrochloride and magnesium sulfate for preterm labor developed rhabdomyolysis. This case highlights a potential adverse effect of prolonged tocolytic therapy.
Area of Science:
- Obstetrics and Gynecology
- Pharmacology
- Neurology
Background:
- Preterm labor necessitates tocolytic therapy to prolong gestation.
- Ritodrine hydrochloride and magnesium sulfate are commonly used agents for managing preterm labor.
Observation:
- A patient with twin gestation received prolonged intravenous therapy with ritodrine hydrochloride and magnesium sulfate for preterm labor.
- After over five weeks of treatment, the patient presented with significant muscle pain.
Findings:
- The patient's muscle pain was diagnosed as rhabdomyolysis.
- This suggests a potential link between prolonged use of ritodrine and magnesium sulfate and the development of rhabdomyolysis.
Implications:
- This case underscores the importance of monitoring for adverse effects during extended tocolytic treatment.
- Further research may be warranted to investigate the incidence and mechanisms of rhabdomyolysis associated with these tocolytic agents.
- Clinicians should consider the risk of rhabdomyolysis in patients receiving long-term ritodrine and magnesium sulfate therapy.