Related Experiment Videos
Intrinsic factors for unbound theophylline
Zenichiro Kato1, Osamu Fukutomi, Naomi Kondo
1Department of Pediatrics, Gifu University School of Medicine, Gifu, Japan. zen-k@cc.gifu-u.ac.jp
Journal of Investigational Allergology & Clinical Immunology
|January 18, 2003
Summary
The unbound theophylline ratio changes with development, impacting clinical use. Intrinsic factors can alter theophylline binding affinity, potentially leading to stronger responses in children at similar total concentrations.
Area of Science:
- Pharmacology
- Clinical Chemistry
- Pediatrics
Background:
- The ratio of unbound theophylline to total serum concentration exhibits developmental changes, indicating potential clinical utility.
- Albumin binding sites for theophylline can be influenced by other molecules, affecting binding affinity.
Purpose of the Study:
- To investigate intrinsic factors that influence the unbound theophylline ratio.
- To understand how these factors affect theophylline's clinical efficacy, particularly in pediatric populations.
Main Methods:
- Analysis of serum samples to determine total and unbound theophylline concentrations.
- Evaluation of various intrinsic patient factors (e.g., age, physiological status) and their correlation with the unbound theophylline ratio.
Main Results:
- Intrinsic factors were identified as significant influencers of the unbound theophylline ratio.
- The study demonstrated variability in theophylline binding affinity due to these intrinsic factors.
Conclusions:
- Physicians should consider intrinsic factors when interpreting total theophylline concentrations.
- A more intense theophylline response may occur in children with certain intrinsic factors, even with equivalent total serum levels.