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[Cochlear cytotoxic activity of cisplatin in experimentation animals. A study using scanning electron microscopy]
R Ramírez Camacho1, J R García Berrocal, A Trinidad
1Servicio de Otorrinolaringología, Clínica Puerta de Hierro, UAM, Madrid. rramirezc@seorl.org
Acta Otorrinolaringologica Espanola
|January 18, 2003
Summary
Cisplatin causes ototoxicity, damaging cochlear cells in rats and guinea pigs. Supporting cells are initially affected, followed by sensory cells, impacting hearing function.
Area of Science:
- Ototoxicity research
- Cellular biology
- Experimental audiology
Context:
- Cisplatin is a widely used chemotherapy drug for solid tumors.
- Ototoxicity and nephrotoxicity are significant dose-limiting side effects of cisplatin.
- Cisplatin-induced ototoxicity serves as a model for studying cochlear damage.
Purpose:
- To investigate the cellular lesions in the cochlea of rats and guinea pigs after intraperitoneal cisplatin administration.
- To evaluate the effects of variable cisplatin doses on cochlear structures at short, middle, and long-term survival.
- To utilize scanning electron microscopy for detailed morphological analysis of cisplatin-induced cochlear damage.
Summary:
- Cisplatin treatment induced dose-dependent cellular lesions in the cochlea of rats and guinea pigs.
- Scanning electron microscopy revealed initial damage to supporting cells of the organ of Corti.
- Later effects included damage to sensory hair cells, indicating progressive cochlear impairment.
Impact:
- Provides a detailed morphological understanding of cisplatin-induced ototoxicity in animal models.
- Highlights the differential vulnerability of cochlear cell types to cisplatin.
- Informs strategies for mitigating cisplatin-related hearing loss in cancer patients.