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Updated: Jul 11, 2026

Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation
Published on: December 26, 2017
[Experimental evaluation of immunotoxicity of olipifat]
A T Belokhvostova1, V B Okulov, L S Potapenkova
1N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Abstract:
The paper presents our data on the influence of Olipifat on the mass and cell patterns of the immune system organs, phagocytic activity of macrophages, number of antibody-producing B-lymphocytes and immune rosette-forming T-lymphocytes. Olipifat showed no immunotoxic characteristics; it stimulated T-system immunity as evidenced by a significant increase in the number of immune rosette-forming T-lymphocytes in mice after injection of 100 or 50 mg/kg.

