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Roles of phospholipase D in apoptosis and pro-survival
1Department of Environmental Cell Responses, Gifu International Institute of Biotechnology, Mitakecho 2193-128, Kanigun, Gifu 505-0116, Japan. nozawa@cc.gifu-u.ac.jp
Biochimica Et Biophysica Acta
|January 18, 2003
Abstract:
Accumulating evidence has recognized phospholipase D (PLD) as an important element in signal transduction of cell responses, including proliferation and differentiation, However, its role in pro-apoptotic, anti-apoptotic or pro-survival signaling is not well-understood. Involvement of PLD in these signaling mechanisms is considered to differ depending on the cell type and the extracellular stimulus.