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Updated: Jul 11, 2026

Ablation of a Single Cell From Eight-cell Embryos of the Amphipod Crustacean Parhyale hawaiensis
Published on: March 16, 2014
Original biological reconstruction of the hip in a 4-year-old girl
Marco Manfrini1, Marco Innocenti, Massimo Ceruso
1Department of Musculo-Skeletal Oncology, Istituto Ortopedico Rizzoli, via Pupilli 1, 40136, Bologna, Italy. marco.manfrini@ior.it
Abstract:
We resected the proximal femur in a 4-year-old child who had Ewing's sarcoma. We reconstructed her hip by an autotransplant of the ipsilateral proximal fibula with its vascular supply, inserted inside a massive bone allograft, and fixed to the residual femur by a plate. Serial postoperative imaging showed the progressive hypertrophy of the transplanted fibula, whose head displayed impressive tridimensional growth inside the acetabulum. 4 years after surgery, hip motility is 100 degrees in flexion, 10 degrees in extension, and 30 degrees in abduction, and the patient's limb is weight bearing.
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