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Related Experiment Videos

Hormone replacement therapy and sleep-disordered breathing.

Eyal Shahar1, Susan Redline, Terry Young

  • 1Division of Epidemiology, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA. shahar@epi.umn.edu

American Journal of Respiratory and Critical Care Medicine
|January 18, 2003
PubMed
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Postmenopausal women using hormone replacement therapy have a significantly lower risk of sleep-disordered breathing. This finding suggests hormone therapy may help prevent or alleviate this condition in older women.

Area of Science:

  • Sleep Medicine
  • Endocrinology
  • Women's Health

Background:

  • Disordered breathing during sleep (sleep-disordered breathing) is more prevalent in postmenopausal women compared to premenopausal women.
  • Declining estrogen and progesterone levels are hypothesized to contribute to this increased prevalence.

Purpose of the Study:

  • To investigate the association between hormone replacement therapy (HRT) use and sleep-disordered breathing (SDB) in postmenopausal women.
  • To determine if HRT influences the occurrence of SDB in women aged 50 and older.

Main Methods:

  • The study analyzed data from 2,852 noninstitutionalized women aged 50+, participants in the Sleep Heart Health Study.
  • Sleep-disordered breathing was assessed using unattended polysomnography to calculate the apnea-hypopnea index (AHI).

Related Experiment Videos

  • Hormone use was recorded, and statistical adjustments were made for factors like age, BMI, and neck circumference.

    • Main Results:

    • The prevalence of SDB (AHI ≥ 15) was approximately halved among hormone users (5.7%) compared to nonusers (14.7%).
    • After multivariable adjustment, the association remained significant (adjusted odds ratio: 0.55; 95% CI: 0.41-0.75).
    • The inverse association was particularly pronounced in women aged 50-59 (adjusted odds ratio: 0.36; 95% CI: 0.21-0.60).

    Conclusions:

    • Hormone replacement therapy use is inversely associated with sleep-disordered breathing in postmenopausal women.
    • HRT may play a role in the prevention or alleviation of SDB.
    • Further research is warranted to confirm causality and explore therapeutic potential.