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CFTR and bicarbonate secretion by [correction of to] epithelial cells
Martin J Hug1, Tsutomu Tamada, Robert J Bridges
1Institute of Physiology, University of Münster, D-48149 Münster, Germany.
Abstract:
Defective HCO(3)(-) and fluid secretion are hallmarks of the pathophysiology of the pancreas of cystic fibrosis patients. Recently, impaired HCO(3)(-) secretion has been shown in most tissues known to express the cystic fibrosis transmembrane conductance regulator (CFTR). New results suggest that CFTR plays an important role in the transcellular secretion of HCO(3)(-).