Related Experiment Video
Updated: Sep 27, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
Do cognitive patterns of brain magnetic activity correlate with hippocampal atrophy in Alzheimer's disease?
F Maestú1, J Arrazola, A Fernández
1Centro de Magnetoencefalografía Dr Pérez Modrego, Universidad Complutense Madrid, 28040 Madrid, Spain.
Background:
Many reports support the clinical validity of volumetric MRI measurements in Alzheimer's disease.
Objective:
To integrate functional brain imaging data derived from magnetoencephalography (MEG) and volumetric data in patients with Alzheimer's disease and in age matched controls.
Methods:
MEG data were obtained in the context of a probe-letter memory task. Volumetric measurements were obtained for lateral and mesial temporal lobe regions.
Results:
As expected, Alzheimer's disease patients showed greater hippocampal atrophy than controls bilaterally. MEG derived indices of the degree of activation in left parietal and temporal lobe areas, occurring after 400 ms from stimulus onset, correlated significantly with the relative volume of lateral and mesial temporal regions. In addition, the size of the right hippocampus accounted for a significant portion of the variance in cognitive scores independently of brain activity measures.
Conclusions:
These data support the view that there is a relation between hippocampal atrophy and the degree of neurophysiological activity in the left temporal lobe.
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