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07:03
Bronchoalveolar Lavage of Murine Lungs to Analyze Inflammatory Cell Infiltration
Published on: May 4, 2017
Inflammatory cells in asthma: mechanisms and implications for therapy
Qutayba Hamid1, Meri K Tulic', Mark C Liu
1Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
The Journal of Allergy and Clinical Immunology
|January 18, 2003
Summary
Asthma involves complex airway inflammation with key cells like eosinophils. Leukotriene receptor antagonists may target these eosinophils, offering therapeutic potential for asthma management.
Area of Science:
- Immunology
- Pulmonology
- Pharmacology
Background:
- Asthma is a chronic airway inflammatory disease.
- Characterized by infiltration of T cells, mast cells, basophils, macrophages, and eosinophils.
- Cysteinyl leukotrienes are key mediators in asthma pathophysiology.
Purpose of the Study:
- To elucidate the complex inflammatory processes in asthma.
- To explore the therapeutic implications of understanding these mechanisms.
- To investigate the role of eosinophils and leukotrienes in asthma.
Main Methods:
- Review of recent clinical studies on asthma inflammation.
- Analysis of cellular and molecular mediators involved in asthma.
- Examination of the role of eosinophils and cysteinyl leukotrienes.
Main Results:
- Asthma involves diverse inflammatory cell infiltration in airways.
- Cysteinyl leukotrienes are significant mediators and modulators in asthma.
- Eosinophil numbers and activation are elevated in asthma, though their exact role is debated.
Conclusions:
- Understanding asthma's inflammatory pathways offers therapeutic insights.
- Leukotriene receptor antagonists may target eosinophils.
- Eosinophils are potential targets for pharmacologic intervention in asthma.
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