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Changes in endogenous tissue glutathione level in relation to murine ascites tumor growth and the anticancer activity
1Cell and Tumor Biology Laboratory, Department of Zoology, School of Life Sciences, North-Eastern Hill University, Shillong, India.
Abstract:
Changes in glutathione levels were determined in tissues of 11- to 12-week-old Swiss albino mice at different stages of Dalton's lymphoma tumor growth and following cisplatin (8 mg/kg body weight, ip) treatment for 24-96 h, keeping 4-5 animals in each experimental group. Glutathione levels increased in spleen of tumor-bearing compared to normal mice (9.95 +/- 0.14 vs 7.86 +/- 1.64 micromol/g wet weight, P
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