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Updated: Sep 27, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
Published on: September 21, 2011
Membrane receptors for steroid hormones: signal transduction and physiological significance
Ilka Nemere1, Richard J Pietras, Peter F Blackmore
1Department of Nutrition and Food Sciences and the Biotechnology Center, Utah State University, Logan 84322, USA. nemere@cc.usu.edu
Abstract:
Membrane receptors for steroid hormones affect signaling pathways that modulate nuclear function, influence neuronal activity, ion flow, and the circulatory system. Indeed, 'new' steroid hormones have been identified by their interaction with membrane-initiated signaling systems. A brief summary of the FASEB Summer Research Conference devoted to these topics is presented in this mini-review. In addition, attendees of the meeting propose introduction of the following terminology: membrane-initiated steroid signaling (MISS) and nuclear-initiated steroid signaling (NISS) to replace more inaccurate terms in current use.
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