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[Cytomegalovirus cellulitis].

Alejandro Ruiz Lascano1, Raquel Kuznitzky, Iliana Garay

  • 1Servicio Dermatología, Hospital Privado de Córdoba, Córdoba, Argentina.

Medicina
|January 21, 2003
PubMed
Summary

Cytomegalovirus (CMV) cellulitis, a rare skin infection, occurred in a kidney transplant patient. Prompt ganciclovir treatment resolved the lesion, highlighting a new manifestation of CMV infection.

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Area of Science:

  • Infectious Diseases
  • Dermatology
  • Transplantation Medicine

Background:

  • Cytomegalovirus (CMV) infection is a known complication in immunocompromised individuals, particularly organ transplant recipients.
  • Cutaneous manifestations of CMV infection are uncommon and typically indicate disseminated disease with a poor prognosis.
  • Standard immunosuppressive therapy post-kidney transplantation involves agents like cyclosporine A and methylprednisolone.

Observation:

  • A 70-year-old female kidney transplant recipient presented with fever, right leg pain, and an erythematous, swollen plaque.
  • Initial treatment with intravenous antibiotics was ineffective.
  • Skin biopsy revealed CMV cytopathic changes, positive immunoperoxidase staining for CMV, and CMV DNA via PCR.

Findings:

  • The skin biopsy confirmed Cytomegalovirus (CMV) infection as the cause of the patient's cellulitis.
  • Histological examination and molecular testing (PCR) were crucial in diagnosing the rare cutaneous manifestation.
  • The patient's condition improved significantly after treatment with ganciclovir.

Implications:

  • This case report describes CMV cellulitis as a novel, treatable cutaneous manifestation of CMV infection.
  • Early recognition and treatment of CMV cellulitis may alter the typically fatal course associated with cutaneous CMV.
  • Highlights the importance of considering opportunistic infections in transplant recipients presenting with unusual skin lesions.

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