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Related Experiment Videos

Expression of human pendrin in diseased thyroids.

Tetsuo Kondo1, Nobuki Nakamura, Koichi Suzuki

  • 1Department of Pathology, Yamanashi Medical University School of Medicine, Japan.

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
|January 21, 2003
PubMed
Summary

Pendrin, a protein involved in thyroid hormone production, is expressed differently in various thyroid diseases. Its expression is reduced in papillary carcinoma, suggesting a role in iodine transport.

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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Pathology

Background:

  • Pendrin is an apical transporter of chloride and iodide.
  • Its role in thyroid hormone production and disease is not fully understood.

Purpose of the Study:

  • To investigate pendrin expression in normal and diseased thyroid tissues.
  • To correlate pendrin expression with thyroid function and disease type.

Main Methods:

  • Immunohistochemistry (IHC) was used to assess pendrin protein levels.
  • Real-time quantitative RT-PCR analyzed pendrin mRNA expression.

Main Results:

  • Pendrin immunoreactivity was stronger in Graves' disease and varied in nodular goiters.
  • Pendrin was negative in follicular and papillary carcinomas.

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  • Pendrin mRNA levels were significantly lower in papillary carcinoma.

    • Conclusions:

    • Pendrin may be involved in thyroid hormone production as a chloride/iodide transporter.
    • Altered pendrin expression is associated with specific thyroid diseases, particularly papillary carcinoma.
    • Further investigation of pendrin aids understanding of thyroid iodine transport.