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The epidermal growth factor receptor as a novel target for cancer therapy: case studies and clinical implications
Jeanne Riddle1, Pamela Lee, Michelle Purdom
1University of Texas M.D. Anderson Cancer Center, 1400 Holcombe Blvd, Box 432, Houston, TX 77030, USA.
Objectives:
To update the success and obstacles using therapies targeted to the epidermal growth factor receptor including IMC-C225, ZD1839, and OSI-774.
Data Sources:
Research articles, textbooks, clinical protocols, case studies.
Conclusions:
Ongoing studies show promise using monoclonal antibodies and small-molecule tyrosine kinase inhibitors in the treatment of non-small cell lung cancer and other malignancies. Such therapies can be delivered with limited toxicity to the host, and initial studies have shown single-agent efficacy and efficacy in combination with chemotherapy and/or radiation therapy.
Implications For Nursing Practice:
Nurses are directly involved in the delivery of these novel therapies and the management of associated toxicities. They serve to coordinate treatment protocols and help to ensure patient understanding and compliance.
Insights
Targeted therapies for epidermal growth factor receptor, including monoclonal antibodies and tyrosine kinase inhibitors, show promise for non-small cell lung cancer and other malignancies with limited toxicity.
Area of Science:
- Oncology
- Pharmacology
Background:
- Review of therapies targeting the epidermal growth factor receptor (EGFR).
- Focus on agents like IMC-C225, ZD1839, and OSI-774.
Observation:
- Ongoing research indicates promise for EGFR-targeted therapies.
- These include monoclonal antibodies and small-molecule tyrosine kinase inhibitors.
Findings:
- EGFR-targeted therapies demonstrate efficacy as single agents or in combination with chemotherapy/radiation.
- These novel treatments exhibit limited host toxicity.
Implications:
- Nurses play a crucial role in administering EGFR-targeted therapies and managing toxicities.
- Coordination of treatment protocols and ensuring patient compliance are key nursing responsibilities.