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Overview of clinical trials with epidermal growth factor receptor inhibitors in advanced non-small cell lung cancer

Melodie Thomas1

  • 1Sarah Cannon Cancer Center and Tennessee Oncology, PLLC, Nashville, TN, USA.

Seminars in Oncology Nursing
|January 22, 2003
PubMed
Abstract

Insights

Epidermal growth factor receptor (EGFR) inhibitors show promise for treating advanced non-small cell lung cancer (NSCLC). ZD1839 demonstrated activity and improved quality of life in phase II trials, with ongoing research for optimal use.

Area of Science:

  • Oncology
  • Molecular Targeted Therapy

Background:

  • Advances in cancer biology have spurred the development of targeted therapies.
  • Epidermal growth factor receptor (EGFR) inhibitors represent a promising class of targeted agents.

Purpose of the Study:

  • To review the clinical development of ZD1839 and other EGFR inhibitors for advanced non-small cell lung cancer (NSCLC).

Main Methods:

  • Literature review of research articles and abstracts.

Main Results:

  • ZD1839 has exhibited clinical activity in phase II trials for NSCLC.
  • Improvements in symptoms and quality of life were observed with ZD1839 treatment.

Conclusions:

  • EGFR inhibitors are a promising therapeutic option for NSCLC.
  • Further trials are investigating the optimal application of ZD1839 and similar agents.
  • Nurses require education on these emerging therapies for patient care and safe administration.

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