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[Methodological and first clinical investigations using a new pancreatic function test].

W Bornschein, F L Goldmann, M Otte

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |February 16, 1976
    PubMed
    Summary

    A novel synthetic peptide effectively screens for pancreatic disorders by measuring p-aminobenzoic acid (PABA) excretion. This indirect pancreatic function test shows high accuracy in distinguishing healthy individuals from those with pancreatic conditions.

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    Area of Science:

    • Biochemistry
    • Gastroenterology
    • Diagnostic Medicine

    Context:

    • Pancreatic exocrine insufficiency is a condition that requires accurate diagnostic methods.
    • Current diagnostic tests for pancreatic function can be invasive or complex.
    • There is a need for a simple, non-invasive screening tool for pancreatic disorders.

    Purpose:

    • To evaluate the efficacy of the synthetic peptide N-benzoyl-L-tyrosyl-p-aminobenzoic acid as a substrate for measuring chymotrypsin activity.
    • To establish a novel indirect pancreatic function test based on p-aminobenzoic acid (PABA) excretion.
    • To assess the clinical utility of this peptide-based test for screening pancreatic disorders.

    Summary:

    • The synthetic peptide N-benzoyl-L-tyrosyl-p-aminobenzoic acid demonstrates chymotrypsin specificity in vitro and in vivo.

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  • Comparative kinetic and clearance tests indicate suitability for an indirect pancreatic function test.
  • Clinical trials show high accuracy, with normal PABA excretion in healthy subjects and correlation with established pancreatic function tests in patients with pancreatic disorders.

    • Impact:

    • This peptide-based test offers a promising, non-invasive screening method for pancreatic exocrine dysfunction.
    • The test correlates well with established measures of pancreatic enzyme activity, such as fecal chymotrypsin concentration.
    • Preliminary results suggest this test could become a valuable tool in the early detection of pancreatopathy.