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Propofol anaesthesia and metabolic acidosis in children
Onur Ozlü1, H Asuman Ozkara, Senay Eris
1Department of Anesthesia, Ankara Children Hospital, Ankara, Turkey. onurozluttnet.net.tr
Insights
Short-term propofol anesthesia in children did not cause significant acidemia or affect liver and heart enzyme levels. Postoperative triglyceride levels were higher with propofol compared to halothane.
Area of Science:
- Pediatric Anesthesiology
- Biochemistry
- Pharmacology
Background:
- Investigating the impact of propofol infusion anesthesia on pediatric acid-base balance and key enzyme levels.
- Assessing biochemical markers in children undergoing short-term anesthesia.
Purpose of the Study:
- To evaluate the effects of propofol versus halothane anesthesia on acid-base status.
- To compare liver and myocardial enzyme levels between propofol and halothane anesthesia in children.
Main Methods:
- Randomized study of 36 children (3-12 years) into propofol (P) and halothane (H) groups.
- Propofol group received 3 mg/kg IV induction and 10-20 mg/kg/hr maintenance.
- Halothane group received thiopental induction and 2-3% halothane maintenance; blood samples collected at multiple time points.
Main Results:
- No significant differences in lactate dehydrogenase, creatine phosphokinase, AST, ALT, or cholesterol between groups.
- Propofol group showed significantly higher postoperative triglyceride levels (P < 0.05).
- Propofol group exhibited significantly lower pH levels post-anesthesia (P < 0.05).
Conclusions:
- Short-term propofol anesthesia in healthy children does not lead to significant acidemia.
- Propofol did not cause notable alterations in hepatic or myocardial enzyme levels.
- Elevated triglycerides were observed post-propofol, warranting further investigation.
Background:
We aimed to investigate the effect of propofol infusion anaesthesia on acid-base status and liver and myocardial enzyme levels of children during short-term anaesthesia.
Methods:
Thirty-six children, aged 3-12 years, were randomized into two groups. In group P (n = 18), induction and maintenance were performed with propofol, 3 mg x kg-1 and 20, 15 and 10 mg x kg-1 x h-1, respectively. In group H (n = 18) following induction with 5 mg x kg-1 thiopenthal, anaesthesia was maintained with 2-3% halothane. Blood samples were obtained following anaesthesia induction and 30, 60 and 120 min after discontinuation of anaesthesia.
Results:
There was no difference in lactate dehydrogenase, myocardial creatininephosphokinase, aspartate aminotransferase, alanine aminotransferase and cholesterol levels between and within the groups. All postoperative triglyceride levels were higher and pH levels were lower in group P than group H (P < 0.05) and there was no difference within the groups.
Conclusions:
In these healthy patients, short-term use of propofol did not result in significant acidaemia, nor alterations in hepatic or myocardial enzyme levels.
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