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Related Experiment Videos

Relationship between goblet cell density and tear function tests.

Anna Chwee Hong Yeo1, Andrew Carkeet, Leo G Carney

  • 1School of Chemical and Life Sciences, Singapore Polytechnic, 500 Dover Road, Singapore 139651, China. yeocwhng@ sp.edu.sg

Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)
|January 22, 2003
PubMed
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Goblet cell density (GCD) does not correlate with common dry eye diagnostic tests in healthy Chinese subjects. Therefore, GCD is not a reliable indicator for tear film instability in normal eyes.

Area of Science:

  • Ophthalmology
  • Optometry
  • Cell Biology

Background:

  • Dry eye disease is a prevalent condition affecting ocular surface health.
  • Accurate diagnostic tests are crucial for identifying and managing dry eye.
  • Goblet cells play a vital role in maintaining the tear film's stability.

Purpose of the Study:

  • To investigate the relationship between goblet cell density (GCD) and standard dry eye diagnostic tests.
  • To assess the utility of GCD as a diagnostic tool for tear film instability in a healthy Chinese population.

Main Methods:

  • 42 healthy Chinese optometry students without prior contact lens wear were enrolled.
  • Standard dry eye tests including non-invasive tear break-up time (NITBUT), phenol red thread test (PRTT), and tear break-up time (TBUT) were performed.

Related Experiment Videos

  • Goblet cell density was determined using impression cytology and PAS-haematoxylin staining, followed by microscopic counting.

    • Main Results:

    • No statistically significant correlation was found between GCD and NITBUT (p=0.222), McMonnies Dry Eye Scores (p=0.742), PRTT (p=0.234), or TBUT (p=0.117).
    • The study utilized Spearman's rho for correlation analysis, with a corrected cumulative familywise error rate of p=0.05.

    Conclusions:

    • Goblet cell density (GCD) is not a reliable standalone diagnostic marker for tear film instability in healthy individuals.
    • While GCD is valuable for diagnosing ocular surface diseases, it does not correlate with common tear function tests in normal eyes.