Related Experiment Videos
Hypomagnesemia after aneurysmal subarachnoid hemorrhage
Walter M van den Bergh1, Ale Algra, Jan Willem Berkelbach van der Sprenkel
1Department of Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands. w.m.vandenbergh@neuro.azu.nl
Neurosurgery
|January 22, 2003
Summary
Hypomagnesemia is common after subarachnoid hemorrhage (SAH) and linked to SAH severity. Magnesium levels between days 2-12 post-SAH can predict delayed cerebral ischemia (DCI).
Area of Science:
- Neurology
- Critical Care Medicine
- Nephrology
Background:
- Hypomagnesemia is a frequent complication in hospitalized patients, often associated with adverse outcomes.
- Aneurysmal subarachnoid hemorrhage (SAH) is a critical neurological condition where electrolyte imbalances, including hypomagnesemia, can occur.
Purpose of the Study:
- To determine the incidence and temporal patterns of hypomagnesemia following SAH.
- To investigate the association between hypomagnesemia, SAH severity, delayed cerebral ischemia (DCI), and patient outcomes.
Main Methods:
- Serum magnesium levels were monitored in 107 SAH patients admitted within 48 hours.
- Hypomagnesemia was defined as serum magnesium <0.70 mmol/L.
- Statistical analyses, including Mann-Whitney U test and multivariate regression, were used to assess relationships.
Main Results:
- Hypomagnesemia was present in 38% of patients at admission and correlated with SAH severity markers.
- Hypomagnesemia during the DCI onset period (Days 2-12) was a significant predictor of DCI (adjusted HR 3.2).
- Hypomagnesemia at admission was associated with poor outcome but did not independently predict it in multivariate analysis.
Conclusions:
- Hypomagnesemia is prevalent post-SAH and linked to SAH severity.
- The development of hypomagnesemia between days 2 and 12 after SAH is a predictor of DCI.