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Related Experiment Videos

Colloid solutions for fluid resuscitation.

F Bunn1, P Alderson, V Hawkins

  • 1Centre for Research in Primary and Community Care (CRIPACC), University of Hertfordshire, College Lane, Hatfield, Hertfordshire, UK, AL10 9PN. f.bunn@herts.ac.uk

The Cochrane Database of Systematic Reviews
|January 22, 2003
PubMed
Summary
This summary is machine-generated.

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This review found no significant difference in safety or effectiveness between colloid solutions for fluid replacement. Larger trials are needed to detect potential differences in mortality rates.

Area of Science:

  • Critical Care Medicine
  • Pharmacology
  • Evidence-Based Medicine

Background:

  • Colloid solutions are frequently used for fluid volume replacement.
  • Variations in molecular weight and characteristics of colloids raise questions about their optimal use.
  • Differences in safety and efficacy among colloid solutions require investigation.

Purpose of the Study:

  • To compare the effects of various colloid solutions in patients requiring fluid volume replacement.
  • To assess the safety and efficacy of different colloid types.

Main Methods:

  • Systematic review of randomized and quasi-randomized trials.
  • Searched multiple databases including Cochrane, MEDLINE, and EMBASE up to September 2002.
  • Extracted data on mortality, blood transfusion amounts, and adverse reactions.

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Main Results:

  • Fifty-seven trials involving 3659 participants were analyzed.
  • No significant differences in mortality were found between albumin/PPF, hydroxyethyl starch (HES), and gelatin.
  • Limited data prevented quantitative analysis of blood transfused; no adverse reactions were reported.

Conclusions:

  • Current evidence does not demonstrate superiority of one colloid solution over another for safety or efficacy.
  • Wide confidence intervals indicate that clinically significant differences cannot be excluded.
  • Larger, well-designed trials are necessary to definitively assess mortality differences.