Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rocuronium versus succinylcholine for rapid sequence induction intubation.

J Perry1, J Lee, G Wells

  • 1Clinical Epidemiology Programme, The Ottawa Hospital, 1053 Carling Avenue, F6 Clinical Epidemiology Programme, Ottawa, Ontario, Canada, K1Y 4E9. jperry@ohri.ca

The Cochrane Database of Systematic Reviews
|January 22, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ex vivo drug screening and clustering of bladder cancers for pre-clinical treatment prediction.

Communications medicine·2026
Same author

Early COVID-19 pandemic modeling: Three compartmental model case studies from Texas, USA.

Computing in science & engineering·2022
Same author

A Short Report Examining the Introduction of Routine Use of Patient-Reported Outcome Measures in a Mixed Oncology Population.

Clinical oncology (Royal College of Radiologists (Great Britain))·2021
Same author

<i>trips4health</i>: Protocol of a single-blinded randomised controlled trial incentivising adults to use public transport for physical activity gain.

Contemporary clinical trials communications·2020
Same author

Improved diagnostic criteria for digital flexor tendon sheath pathology using contrast tenography.

Equine veterinary journal·2019
Same author

When is a randomised controlled trial health equity relevant? Development and validation of a conceptual framework.

BMJ open·2017
Same journal

Interventions to prevent or cease electronic cigarette use in children and adolescents.

The Cochrane database of systematic reviews·2026
Same journal

Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

The Cochrane database of systematic reviews·2026
Same journal

Interventions for smoking cessation in inpatient psychiatry settings.

The Cochrane database of systematic reviews·2026
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
See all related articles

Succinylcholine provides better endotracheal intubation conditions than rocuronium. However, when propofol is used for induction, both drugs offer similar intubation success rates, with no major adverse events reported.

Area of Science:

  • Anesthesiology
  • Critical Care Medicine
  • Pharmacology

Background:

  • Rapid sequence induction intubation (RSI) is crucial for emergent airway management.
  • Succinylcholine is a common neuromuscular blocker but carries risks like hyperkalemia.
  • Rocuronium is a potential alternative, but its efficacy compared to succinylcholine requires clarification.

Purpose of the Study:

  • To compare the efficacy of rocuronium versus succinylcholine for endotracheal intubation during RSI.
  • To evaluate intubating conditions based on various factors including induction agent and patient population.

Main Methods:

  • A meta-analysis of randomized controlled trials and controlled clinical trials was conducted.
  • Searches included MEDLINE, EMBASE, and Cochrane Central Register.

Related Experiment Videos

  • Intubation conditions were assessed using a four-point scale, with primary outcome being excellent conditions.

    • Main Results:

    • Overall, succinylcholine yielded superior intubation conditions compared to rocuronium (RR=0.87).
    • When propofol was the induction agent, intubating conditions were comparable between the two drugs (RR=0.96).
    • No significant adverse events were reported for either agent.

    Conclusions:

    • Succinylcholine is more effective for achieving excellent intubation conditions.
    • Rocuronium and succinylcholine show similar efficacy for clinically acceptable intubation conditions.
    • The choice between rocuronium and succinylcholine may depend on the induction agent, particularly propofol.