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Related Experiment Videos

Interventions for treating collagenous colitis.

N Chande1, J W McDonald, J K MacDonald

  • 1c/o 5-OF 12 LHSC-UC, 339 Windermere Road, London, Ontario, Canada, N6A 5A5. nchande@uwo.ca

The Cochrane Database of Systematic Reviews
|January 22, 2003
PubMed
Summary
This summary is machine-generated.

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Budesonide effectively treats collagenous colitis, showing significant clinical and histological improvement. Bismuth subsalicylate also shows promise for chronic diarrhea treatment.

Area of Science:

  • Gastroenterology
  • Colorectal Diseases
  • Pharmacology

Background:

  • Collagenous colitis is a recognized cause of chronic diarrhea.
  • Current treatment strategies largely rely on anecdotal evidence.
  • This review aimed to identify therapies with proven efficacy from randomized trials.

Purpose of the Study:

  • To determine effective treatments for collagenous colitis.
  • To evaluate therapies based on evidence from randomized controlled trials.

Main Methods:

  • Comprehensive literature search of MEDLINE, PUBMED, EMBASE, and Cochrane databases (1970-2002).
  • Inclusion of randomized trials and abstracts from major gastroenterological meetings.
  • Data extraction and analysis using chi-square tests and Peto odds ratios for efficacy assessment.

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Main Results:

  • Budesonide demonstrated significant clinical and histological improvement in 3 trials (n=94), with a pooled odds ratio of 12.32 (95% CI 5.53-27.46) and NNT of 2.
  • Bismuth subsalicylate showed significant clinical and histological improvement in one trial (n=9), with p=0.003 for both outcomes.
  • All budesonide trials reported significant histological improvement.

Conclusions:

  • Budesonide is an effective treatment for collagenous colitis.
  • Bismuth subsalicylate provides weaker but still important evidence for treatment efficacy.
  • The roles of these therapies in inducing or maintaining remission remain unknown.