Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prophylactic antibiotic therapy for chronic bronchitis.

T Staykova1, P N Black, E E Chacko

  • 1Dept of Medicine, University of Auckland, New Zealand. pn.black@auckland.ac.nz

The Cochrane Database of Systematic Reviews
|January 22, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microengineering Laser Plasma Interactions at Relativistic Intensities.

Physical review letters·2016
Same author

Author reply: To PMID 24863137.

Internal medicine journal·2015
Same author

Medical service redesign shares the load saving 6000 bed days and improving morale.

Internal medicine journal·2014
Same author

Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: does it also reduce atopic sensitization?

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2013
Same author

Coherent anti-Stokes Raman scattering and spontaneous Raman spectroscopy and microscopy of microalgae with nitrogen depletion.

Biomedical optics express·2012
Same author

Surface-enhanced Raman spectroscopy using gold-coated horizontally aligned carbon nanotubes.

Nanotechnology·2012

Prophylactic antibiotics may reduce illness days for chronic bronchitis exacerbations but are not recommended for routine use due to resistance concerns and side effects. This finding is based on older studies.

Area of Science:

  • Respiratory Medicine
  • Clinical Pharmacology

Background:

  • The efficacy of prophylactic antibiotics for managing chronic bronchitis exacerbations remains a subject of debate.
  • Acute exacerbations significantly impact the quality of life and disease severity in chronic bronchitis patients.

Purpose of the Study:

  • To evaluate the effectiveness of prophylactic antibiotics in reducing the frequency of exacerbations and associated disability days in chronic bronchitis patients.
  • To synthesize evidence from randomized controlled trials on antibiotic prophylaxis for chronic bronchitis.

Main Methods:

  • Systematic review and meta-analysis of randomized controlled trials (RCTs) identified through comprehensive literature searches.
  • Eligibility criteria focused on trials involving prophylactic antibiotic use in patients with chronic bronchitis or COPD.

Related Experiment Videos

  • Data extraction and analysis were performed by three independent reviewers to ensure reliability.

    • Main Results:

    • Nine trials (1055 subjects) published before 1970 were included; allocation concealment was adequate in only three.
    • Prophylactic antibiotics showed a statistically significant reduction in the likelihood of experiencing an exacerbation (RR 0.91, 95% CI 0.84-0.99).
    • A significant reduction was observed in disability days per patient per month (WMD -0.95, 95% CI -1.89 to -0.01) and per exacerbation (WMD -2.08, 95% CI -4.08 to -0.07), with a slight increase in adverse effects.

    Conclusions:

    • Prophylactic antibiotics offer a modest benefit in reducing illness duration for chronic bronchitis exacerbations.
    • Concerns regarding antibiotic resistance and adverse effects, coupled with outdated data, preclude their routine use in chronic bronchitis management.
    • The evolving landscape of antibiotic resistance and available treatments necessitates updated research in this area.