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A genomics-guided approach for discovering and expressing cryptic metabolic pathways
Emmanuel Zazopoulos1, Kexue Huang, Alfredo Staffa
1Ecopia BioSciences, Inc., 7290 Frederick Banting, Montreal, Quebec H4S 2A1, Canada.
Nature Biotechnology
|January 22, 2003
Summary
Scientists discovered a new method to find dormant gene clusters in actinomycetes, revealing pathways for enediyne antitumor antibiotics. This breakthrough expands the known diversity of natural products and aids drug discovery.
Area of Science:
- Genomics and Molecular Biology
- Natural Product Biosynthesis
- Microbial Biochemistry