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[Relationship between the level of plasma D-dimer and diabetic microangiopathy]
1Department of Gerontology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Objective:
To study the relationship between the level of plasma D-dimer and microangiopathy of the type 2 diabetes mellitus.
Methods:
The level of plasma D-dimer and blood viscosity were measured in 52 cases with type 2 diabetes mellitus, and these patients were divided into three groups according to the level of urinary albumin excretion (UAE) together with 15 age-matched healthy volunteers as the control (NC group).
Results:
In the cases with higher urinary albumin excretion rate, including 28 cases with trace albuminuria (EDN group) and 10 cases with clinical albuminuria (CDN group), plasma D-dimer and blood viscosity were increases than 14 cases without albuminuria (SDM group) and NC group. D-dimer was positively correlated with diabetic retinopathy, Serum insulin and diabetic durations, but not correlated with blood viscosity and fibrinogen.
Conclusion:
The type 2 diabetes mellitus complicated with microangiopathy had a higher level of plasma D-dimer. As a marker of thrombus formation, D-dimer may play an important role in the pathogenesis of diabetic microangiopathy.
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