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Published on: November 16, 2011
[Relationship between basic fibroblast growth factor (bFGF) and cell proliferation, invasion in pituitary adenoma]
1Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Abstract:
Basic fibroblast growth factor (bFGF) and proliferating cell nuclear antigen (PCNA) were examined by immunohistochemistry in fifty-one pituitary adenomas. The results showed that the intensity of bFGF expression was strong or intermediate in twenty-nine adenomas, which was positively related to cell proliferation, there was positive relationship between bFGF expressin and tumor invasion in non-functional adenomas. The data suggest that bFGF may play some role in the origin and progression of pituitary adenomas.
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