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[The effect of rIFN alpha-2b on mice NK cell activity]
Hua Xi Yi Ke Da Xue Xue Bao = Journal of West China University of Medical Sciences = Huaxi Yike Daxue Xuebao
|January 23, 2003
Abstract
Objective:
This animal experiment was made to study the effect of the recombined interferon alpha-2b(rIFN alpha-2b) on natural killer cells activity of mice spleen in vivo, and by way of this, to test the activity of rIFN alpha-2b.
Methods:
BALB/c mice were given rIFN alpha-2b subcutaneously. The inhibiting 3H-TdR intaking method was used to test the NK activity of spleen cells of BALB/c mice.
Results:
The NK cell activity levels of the high-dose group, the mid-dose group and the low-dose group were 65.19 +/- 17.56, 44.19 +/- 14.30 and 35.46 +/- 17.49, respectively.
Conclusion:
rIFN a-2b can enhance NK cells activity observably and its effect is dose dependent.