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Updated: Sep 25, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Published on: February 21, 2018
[Expression of bcl-2, c-myc genes and their relationship in patients with acute leukemia]
1Department of Hematology, Xiangya Hospital, Central South University, Changsha 410078.
Objective:
This paper was to explore the expressions of bcl-2, c-myc genes and the relationship between them in bone marrow from patients with acute leukemia (AL).
Methods:
In situ hybridization was used to detect bcl-2 and c-myc mRNA. Immune cytochemistry was used to detect bcl-2 and c-myc protein.
Results:
The expressions of bcl-2, c-myc mRNA and proteins were significantly increased in AL; There were not significant differences in bcl-2 mRNA and protein, c-myc mRNA and protein between the patients with acute lymphocytic leukemia and acute nonlymphocytic leukemia; There were linear correlations between bcl-2 mRNA and bcl-2 protein, between c-myc mRNA and c-myc protein, between bcl-2 mRNA and c-myc mRNA, between bcl-2 protein and c-myc protein.
Conclusion:
bcl-2 and c-myc genes play an important role in pathogenesis and the development of AL.
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