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[Study on p53 gene expression following transient ischemia in the gerbil]
1Institute of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University
|January 23, 2003
Abstract
Objective:
To study the expression of p53 gene after transient ischemia in the gerbil.
Methods:
Northern blot was used to detect the expression of the p53 mRNA in the forebrain during different periods after post-ischemic reperfusion in the gerbil.
Results:
The expression of p53 mRNA increased in the forebrain during the 6th hour to the 3rd day of reperfusion following 6 min of ischemia (P < 0.05).
Conclusion:
The high level expression of p53 might induce neuronal apoptosis after ischemia.