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[Study on endothelial dysfunction and platelet activation in elderly hypertensive patients complicated with cerebral
1Department of Cardiology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Objective:
The aim of this paper was to investigate endothelial dysfunction, platelet activation, and inflammation in elderly hypertensive patients and those complicated with cerebral infarction.
Methods:
Twenty-eight elderly hypertensive patients complicated with cerebral infarction(within 72 hours after onset of neurological symptoms), thirty-one Stage I-II elderly hypertensive patients and twenty-eight elderly healthy individuals were selected as subjects. Their plasma concentrations of von Willebrand factor(vWF), alpha granule membrane protein-140(GMP-140), and serum concentrations of C-reaction protein(CRP) were examined.
Results:
Elderly hypertensive patients complicated with cerebral infarction had significantly higher plasma vWF, GMP-140, and serum CRP than elderly hypertensive patients and elderly healthy individuals. Plasma vWF and GMP-140 were higher in elderly hypertensive patients than elderly healthy individuals, whereas serum CRP was increased slightly and there was no significant difference between elderly hypertensive patients and elderly healthy individuals.
Conclusion:
This study suggests that elderly hypertensive patients complicated with cerebral infarction have obvious endothelial dysfunction, platelet activation, and inflammatory change. Stage I-II elderly hypertensive patients have obvious endothelial dysfunction and platelet activation as well.