Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Minimal brain dysfunction: a hydraulic parfait model.

L E Arnold

    Diseases of the Nervous System
    |April 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    This study suggests that conditions like MBD (Methyl-Binding Domain) and behavioral or learning disorders may stem from accumulating pathologies. Understanding these diverse causes is key for personalized treatment plans and accurate diagnosis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Diffusion imaging markers of bipolar versus general psychopathology risk in youth at-risk.

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2018
    Same author

    Reward-related neural activity and structure predict future substance use in dysregulated youth.

    Psychological medicine·2016
    Same author

    Predicting clinical outcome from reward circuitry function and white matter structure in behaviorally and emotionally dysregulated youth.

    Molecular psychiatry·2016
    Same author

    Behavioral and emotional dysregulation trajectories marked by prefrontal-amygdala function in symptomatic youth.

    Psychological medicine·2014
    Same author

    A Fuller History of the PRITE.

    Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry·2014
    Same author

    Positive effects of methylphenidate on hyperactivity are moderated by monoaminergic gene variants in children with autism spectrum disorders.

    The pharmacogenomics journal·2013

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Developmental Psychology

    Background:

    • Behavioral and learning disorders often co-occur, suggesting shared underlying mechanisms.
    • Current diagnostic approaches may not fully capture the complexity of etiological factors.
    • The concept of psychophysiologic disorders highlights the interplay between psychological and physiological processes.

    Purpose of the Study:

    • To explore the overlap between Methyl-Binding Domain (MBD) disorders, behavioral disorders, and learning disorders.
    • To conceptualize symptom production and diagnosis triggering through a multidimensional etiological framework.
    • To propose a research direction for developing etiological profiles in individual patients.

    Main Methods:

    • Utilized a Venn diagram to visualize the overlap between MBD, behavioral disorders, and learning disorders.

    Related Experiment Videos

  • Employed a hydraulic parfait model to illustrate the additive accumulation of pathology leading to symptom production.
  • Applied a similar hydraulic model to conceptualize diagnosis-triggering based on cumulative symptom pressure.
  • Main Results:

    • The models suggest that disorders like MBD, behavioral, and learning disorders may represent a spectrum of psychophysiologic conditions.
    • Symptom accumulation from various etiologies can lead to disorder manifestation.
    • Diagnostic thresholds vary among clinicians, impacting the "trigger pull" for diagnosis.

    Conclusions:

    • A multidimensional understanding of etiologies is crucial for tailoring treatment plans.
    • Developing etiological profiles for individual patients could enhance diagnostic accuracy and treatment efficacy.
    • Further research correlating symptom spectra with etiological profiles is warranted.