[Study on histology and the expression of Bax and Bcl-2 after cerebral contusion in rats]

To set up the experimental model of focal cerebral contusions in rats, and to study the histology and the expression of Bax and Bcl-2 after cerebral catusions. It was found that neurons and astrocytes around the wound area were changed morphologically and that polymorphonuclear leucocytes were present at 12-24 h after injury. A lot of foamy cells and astrocytes having a big dark nucleus appeared around the wound area on the 4th day after injury. On the 8-10th day, liquefaction necrosis was seen in areas of contusions. On the 12-14th day, the contusion focus healed up and became cystiform or glial node. Meantime, lots of astrocytes, capillary vessel and hemosiderin were observed. The expression of Bax and Bcl-2 increased after injury. There existed a relationship between increased Bax/Bcl-2 and different intervals after brain injury.