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Convenient synthesis of fluorinated nucleosides with perfluoroalkanesulfonyl fluorides
Satoshi Takamatsu1, Satoshi Katayama, Naoko Hirose
1AminoScience Laboratories, Ajinomoto Co., Inc., 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki 210-8681, Japan. satoshi_takamatsu@ajinomoto.com
Nucleosides, Nucleotides & Nucleic Acids
|January 23, 2003
Abstract:
Perfluoroalkanesulfonyl fluorides are effective dehydroxy-fluorination agents for the hydroxyl group at the sugar moiety of nucleoside derivatives and give the corresponding fluorinated nucleosides in good yield with an inversion of configuration in a single step.